A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells
Research output: Contribution to journal › Journal article › Research › peer-review
Specific recognition of peptide/major histocompatibility complex (MHC) molecule complexes by the T-cell receptor is a key reaction in the specific immune response. Antibodies against peptide/MHC complexes would therefore be valuable tools in studying MHC function and T-cell recognition and might lead to novel approaches in immunotherapy. However, it has proven difficult to generate antibodies with the specificity of T cells by conventional hybridoma techniques. Here we report that the phage display technology is a feasible alternative to generate antibodies recognizing specific, predetermined peptide/MHC complexes.
Original language | English |
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Journal | Proceedings of the National Academy of Science of the United States of America |
Volume | 93 |
Issue number | 5 |
Pages (from-to) | 1820-4 |
Number of pages | 4 |
ISSN | 0027-8424 |
Publication status | Published - 1996 |
Bibliographical note
Keywords: Amino Acid Sequence; Animals; Antibody Specificity; Bacteriophages; Gene Library; Major Histocompatibility Complex; Mice; Mice, Inbred AKR; Molecular Sequence Data; Peptides; Recombinant Proteins; T-Lymphocytes
ID: 9945624